WebOct 20, 2024 · Five hits were identified, all related to BTN3A isoforms demonstrating ICT01 specificity (fig. S2, A and B). ICT01 was … WebAll lanes : Anti-BTN3A1 antibody [4E1B9] (ab233781) at 1/500 dilution Lane 1 : Untransfected HEK-293 (human epithelial cell line from embryonic kidney) cell lysate …
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells
WebRecombinant Human BTN3A1 protein (Fc Chimera His Tag) is a Baculovirus infected insect Protein fragment 30 to 254 aa range, > 90% purity, < 1.000 Eu/µg endotoxin level and … WebThe mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A hallmark of the T cell response is the ability of T cells to quantitatively respond to antigenic ligands derived from … the salty twins
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WebBTN3A1 is a butyrophilin-like protein related to CD80, PD-L1, and MHC, and is either a presenting or a co-stimulatory molecule for PAgs. Although the precise roles and molecular interactions with the TCRVγ9Vδ2 are currently not determined, it is commonly thought that all TCRVγ9Vδ2 lymphocytes 'see' PAg and BTN3A1 together, presumably in a ... WebOct 15, 2024 · Vγ9Vδ2 + T cell-targeted immunotherapy is of interest to harness its MHC-independent cytotoxic potential against a variety of cancers. Recent studies have identified heterodimeric butyrophilin (BTN) 2A1 and BTN3A1 as the molecular entity providing "signal 1" to the Vγ9Vδ2 TCR, but "signal 2" costimulatory requirements remain unclear. WebAll lanes : Anti-BTN3A1 antibody [4E1B9] (ab233781) at 1/500 dilution Lane 1 : Untransfected HEK-293 (human epithelial cell line from embryonic kidney) cell lysate Lane 2 : Human BTN3A1 (aa 30-254)-hIgG-Fc-transfected HEK-293 … the salty toad waukesha