Dysregulation of lipid metabolism
WebInhibition of HIF-2α protein reversed lipid metabolism dysregulation induced by acute hypoxia in HepG2 cells, which suggested that HIF-2α signaling may be relevant to oxygen … WebAug 23, 2016 · Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, …
Dysregulation of lipid metabolism
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WebAccumulation of IHTG is likely due to an imbalance between fatty acid delivery, synthesis and removal (via oxidation or export as TAG) from the liver; insulin plays a key role in all … WebThere are three processes of lipid metabolism in macrophages: cholesterol uptake, esterification, and efflux. However, during atherosclerosis, dysregulation of lipid …
WebThe most discriminant lipidic molecules between the three groups of patients, estimated according to their Variable Importance in Projection (VIP) score (threshold > 2.0) included … WebJul 29, 2024 · TH regulates the metabolism of fatty acids and the disruption of TH function in the liver contributes to the development of MAFLD. Previous studies reported that cellular TH signaling is altered in several liver-related diseases, including MAFLD and hepatocellular carcinoma (HCC) [ 48 ].
WebJun 27, 2024 · Non-alcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD (both simple steatosis and steatohepatitis) is characterized by alterations in hepatic lipid metabolism, which may lead to the development of severe liver complications including cirrhosis and hepatocellular carcinoma. WebA further aspect of lipid dysregulation promoting PD pathogenesis is oxidative stress and inflammation, with proinflammatory lipid mediators such as platelet activating factors (PAFs) playing key roles in arbitrating …
WebThere are three processes of lipid metabolism in macrophages: cholesterol uptake, esterification, and efflux. However, during atherosclerosis, dysregulation of lipid metabolic pathways leads to the accumulation of foam cells in the intima of …
WebApr 15, 2024 · Combined maternal and postnatal high-fat (HF) diet intake predisposes offspring to metabolic dysregulation during adulthood. As the inhibitory effects of leucine consumption on obesity and metabolic disorders have been reported, the effects of maternal leucine supplementation on metabolic dysregulation in adult offspring were … impact of climate change on public healthWebApr 24, 2024 · Then, metabolism dysregulations were investigated in both patients and murine models. Alterations of elongase and desaturase activities were observed along … list t binarysearchWebOct 21, 2016 · Hypercaloric diets lead to the dysregulation of multiple lipid metabolic pathways, which contributes to the onset and progression of metabolic disease. list teaching strategiesWebMar 9, 2024 · 1. Introduction. Asthma is characterized by airway hyper-responsiveness, mucus hypersecretion, infiltration of the airway by eosinophils and type 2 (T2) immune … impact of climate change on protected areasWebDysregulation of lipids in Alzheimer's disease and their role as potential biomarkers. The brain is highly enriched in lipids, and an intensive study of these lipids may be … impact of climate change on river flowWebMay 26, 2016 · We discuss the mechanisms by which the core molecular clock drives rhythms in lipid biosynthesis and catabolism in different metabolic tissues, as well as the … impact of climate change on poorer countriesWebWe used bioinformatic analysis and examined changes in lipid metabolism in HCC cells in response to matrix stiffness. Moreover, ACADL was identified as a key enzyme, initiating … impact of climate on tourist demand